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japonicum and human Scribble orthologs were revealed. Divergent ligand specificities between the homologous PDZ domains of S. In this study, by yeast two-hybrid screening of a random library, we confirmed the ligand binding properties of a multiple PDZ domain-containing protein Scribble of S. So far, however, little is known about ligand binding specificities and the molecular functions of parasite-derived PDZ domain-containing proteins. japonicum, a panel of PDZ domains is conserved in this species. Although domain loss events are widespread in S. A number of compounds screened based on binding specificities of PDZ domains have shown their potential therapeutic power in several disease models with less side effects. The PDZ domain is one of the most important modules for PPIs. Protein-protein interactions (PPIs), for highly discriminating specificities, are thought to be the innovative targets for a generation of new drugs. The long-term of treatments with the only available drug, praziquantel, has raised the concerns about drug resistance. Schistosomiasis japonica remains a major public health problem in China and Southeast Asia.

We also compared the differences in ligand specificities between SjScrib-PDZs and hScrib-PDZs, and explored the structural basis for the ligand binding properties of SjScrib-PDZs. The irregular and unconventional internal ligand binding specificities for the PDZ domains of SjScrib were confirmed by point mutations of the key amino acids within the ligand binding motifs. SjScrib-PDZ4 binds to typical II C-terminal PBMs with a consensus sequence -, in which the aromatic residue Phe is predominantly selected at position -4. SjScrib-PDZ2 prefers stringent type II C-terminal PBMs, which significantly differs from that of its human ortholog. Both SjScrib-PDZ1 and SjScrib-PDZ3 recognize type I C-terminal PDZ-domain binding motifs (PBMs), which can be deduced as consensus sequences of - and -, respectively. By screening an arbitrary peptide library in yeast two-hybrid (Y2H) assays, we identified and confirmed the ligand binding specificity for each of the four PDZ domains of SjScrib. Note: if we do not have your banking details, we will pay the claims your practice submits to our members.The gene encoding the Schistosoma japonicum Scribble protein (SjScrib) was identified by homologous search with the S.

#Discovery pro pbm contact number registration#

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#Discovery pro pbm contact number professional#

Completed Healthcare professional practice management and web access details form.Completed Healthcare professional banking details for the payment of claims form.VAT registration document (if applicable).

#Discovery pro pbm contact number license#

We settle claims promptly and with the highest possible level of accuracy. Registering your pharmacy at Discovery HealthĠ860 44 55 your pharmacy to receive payment from Discovery Health

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NAPPI Code Registration and Review Process Guide Surgical Drug considerations (only SAHPRA registered schedule 3-6 products)Ĭenter of Clinical code registration and review process Who to contact Real-time medicine claim and price queriesĠ860 776 medicine authorisation / confirming benefitsĠ860 445 supplier price files/product information, out of stock notificationsĠ860 776 Technology Assessment (HTA) process,Īpproved product lists, Approval for Digital technologies & new equipment, annual price adjustments